The 22-time Grammy winner says during almost 50 years in music, he and bandmates Adam Clayton, The Edge and Larry Mullen Jr have all tried to throw in the towel at some stage.
Bono reveals: “I have certainly thought about walking away from U2, every member has. We have all thought about it.
“It is the right instinct to question whether this should still be going and what it demands of all four members.
“But the reason why I want to go forward is something is stirring in my voice and my singing and the desire to write songs we don’t have yet. We are chasing the dragon of the song we can’t get.”
In their new Disney+ documentary A Kind Of Homecoming, he told David Letterman: “The real magic of U2 is that everything we needed, the people we needed, were always right there.”
The fact they are still standing united as a band is something The Edge describes as “remarkable”, admitting Bono’s desire to be a political activist pushed them to their limit on countless occasions.
The guitarist says: “The fact we are still together is a remarkable thing. We kind of grew up together and learnt how to be people of the world via the band.
“We are probably a little institutionalised by being in this thing a little too long. There are many times in the past I think we were pushing our look a little too far. It was hard for us. There was a lot of tension.”
In the special, out next Friday, Bono adds: “Friendship is deeply part of who we are, but you could lose that along the way. We had to work on it.
“Yes, I embarrass the band. I accept my activism is fairly unhip work.
“If you are in a rock and roll band, you don’t want to be in the photograph with some people who might have polarising opposite values you hold dear, and I did that to them.
“I am turning what we created as a band into currency that I chose to spend in these areas.
“By and large they support me, but I do know I test their patience.”
Continuing with his life of campaigning, Bono also uses the 90-minute documentary to call for a united Ireland, although he is keen not to lay all the blame about the country’s problems on the United Kingdom.
Bono said: “I hope it will be in my lifetime when the border goes away.
“It is kind of ridiculous having a border on an island this size and the North and the South will have more respect for each other. That would be nice.”
BEETLEJUICE 2 is finally happening, with Jenna Ortega in talks to appear in the film.
Director Tim Burton is planning to begin production in London during May, with Michael Keyton and Winona Ryder ready to reprise their roles.
Tim worked with Jenna on Netflix series Wednesday and now wants her on board for the spooky sequel as the daughter of Lydia, who is played by Winona.
The original came out in 1988 and became a huge hit, even winning an Oscar.